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Study details
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IN Midazolam vs IN Dexmedetomidine vs IN Ketamine During Minimal Procedures in Pediatric ED

University of Oklahoma
NCT IDNCT05934669ClinicalTrials.gov data as of Apr 2026
Phase

Phase 4

Target enrollment

90

Study length

about 1.6 years

Ages

1–5

Locations

1 site in OK

What this study is about

This trial is testing whether intranasal midazolam, dexmedetomidine, or ketamine are better for children who need minor procedures like laceration repairs. The goal is to see which medication helps kids stay calm and have a shorter time in the emergency department while also making both patients and doctors happy.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take Intranasal Dexmedetomidine
  • 2.Take Intranasal Ketamine
  • 3.Take Intranasal Midazolam

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
intranasalintranasal

How treatment is administered

Treatment Assignment
Randomized & Blinded

You may get a placebo/standard care, and you won't know which.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

dexmedetomidine, ketamine (NMDA receptor antagonist; induces dissociative anesthesia and analgesia), midazolam (Benzodiazepine; short-acting)

Drug routes

intranasal, injection

Body systems

Dermatology, Psychiatry / Mental Health