Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty
Phase 4
148
about 4.3 years
50+
1 site in TN
What this study is about
Researchers are testing whether a treatment called GlyNAC (a combination of glycine and n-acetylcysteine) reduces oxidative stress and chronic post surgical pain in people undergoing total knee arthroplasty. The trial will last for 1576 days.
Simplified from trial records by PatientMatch.
What you may be asked to do
- 1.Take GlyNAC (combination of glycine and n-acetylcysteine)
- 2.Take Placebo
Participation Burden
What's physically and logistically required of participants.
Requires travel to a study site
How treatment is administered
You may get a placebo/standard care, and you won't know which.
Extracted study details
Pulled from the trial record to show what is being tested and what the study is measuring.
acetylcysteine, BLOOD AND BLOOD FORMING ORGANS
oral (Oral Capsule)
Primary: Numeric Rating Scale (NRS) Rating of Worst Pain in the past 24 hours
Secondary: Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS-JR), Mean change in McGill Pain Questionnaire-2 (MPQ-2) ratings of knee pain for average pain over past week of measurement., Numeric Rating Scale (NRS) Rating of Worst Pain in the past 24 hours, Numeric Rating Scale of Average Pain in the past 24 hours, Numeric Rating Scale of Least Pain in the past 24 hours, PROMIS Short Form V1.0 - Pain Interference 8a scale
Musculoskeletal