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Study details
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A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide

Eli Lilly and Company
NCT IDNCT06897475ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

240

Study length

about 1.8 years

Ages

18–75

Locations

25 sites in AZ, CA, FL +11

What this study is about

Researchers are testing whether LY3457263, compared to placebo, can help lower hemoglobin A1c (HbA1c) levels in adults with type 2 diabetes who are already taking semaglutide or tirzepatide. The trial will last about 9 months.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take LY3457263
  • 2.Take Placebo

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
Randomized & Blinded

You may get a placebo/standard care, and you won't know which.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Endpoints

Primary: Change from Baseline in Hemoglobin A1c (HbA1c)

Secondary: Change from Baseline in Fasting Serum Glucose, Percent Change from Baseline in Body Weight

Body systems

Endocrinology